Wald-Klinikum GeraWald-Klinikum Gera

Originalarbeiten (peer-reviewed)

  1. Hinze R, Boltze C, Meye A, Holzhausen HJ, Dralle H, Rath FW (2000)
    Expression of the von Hippel-Lindau tumor suppressor gene in nonneoplastic and neoplastic lesions of the thyroid.
    Endocr Pathol, 11:145-155
  2. Boltze C, Schneider-Stock R, Jäger V, Roessner A (2001)
    Distinction between lipoma and liposarcoma by mdm2 alterations: a case report of simultaneously occurring tumors and review of the literature.
    Pathol Res Pract, 197:563-568
  3. Aust G, Steinert M, Boltze C, Kiessling S, Simchen C (2001)
    GRO in normal and pathological thyroid tissues and its regulation in thyroid-derived cells.
    J Endocrinol, 170:513-520
  4. Hribaschek A, Kuhn R, Pross M, Lippert H, Halangk W, Boltze C, Ridwelski K (2001)
    Prophylaxis of peritoneal carcinomatosis in experimantal investigations.
    Int J Colorectal Dis, 16:340-345
  5. Boltze C, Brabant G, Dralle H, Gerlach R, Roessner A, Hoang-Vu C (2002)
    Radiation-induced thyroid carcinogenesis as function of time and dietary iodine supply - An in-vivo model of tumorigenesis in the rat.
    Endocrinology, 143:2584-2592
  6. Mawrin C, Lins H, Koenig B, Heinrichs T, Murayama S, Kirches E, Boltze C, Dietzmann K (2002)
    Spatial and temporal disease progression of adult-onset subacute sclerosing panencephalitis.
    Neurology, 58:1568-1571
  7. Boltze C, Schneider-Stock R, Aust G, Mawrin C, Dralle H, Roessner A, Hoang-Vu C (2002)
    CD97, CD95 and Fas-L clearly discriminate between chronic pancreatitis and pancreatic ductal adenocarcinoma in perioperative evaluation of cryocut sections.
    Pathol Int, 52:83-88
  8. Mawrin C, Kirches E, Boltze C, Dietzmann K, Roessner A, Schneider-Stock R (2002)
    Immunohistochemical and molecular analysis of p53, Rb and PTEN in malignant peripheral nerve sheath tumors.
    Virchows Arch, 440:610-615
  9. Ondruschka C, Buhtz P, Motsch C, Freigang B, Schneider-Stock, Roessner A, Boltze C (2002)
    Prognostic value of MMP-2, -9 and TIMP-1, -2 immunoreactive protein at the invasive front in advanced head and neck squamous cell carcinomas.
    Pathol Res Pract, 198:509-515
  10. Steinert M, Wobus M, Boltze C, Schütz A, Wahlbuhl M, Hamann J, Aust G (2002)
    Expression and regulation of CD97 on colorectal cell lines and carcinomas.
    Am J Pathol, 161:1657-1667
  11. Schneider-Stock R, Boltze C, Roessner A (2002)
    Telomerase and new aspects for tumor.
    Pathologe, 23:177-182
  12. Mawrin C, Kirches E, Boltze C, Dietzmann K (2002)
    PTEN is not altered in sporadic vestibular schwannomas.
    Histopathology, 40:526-531
  13. Boltze C, Roessner A, Landt O, Szibor R, Peters B, Schneider-Stock R (2002)
    Homozygous proline at codon 72 of p53 as a potential risk factor favoring the development of undifferentiated thyroid carcinoma.
    Int J Oncol, 21:1151-1154
  14. Hoang-Vu C, Boltze C, Gimm O, Poremba C, Dockhorn-Dworniczak B, Köhrle J, Rath FW, Dralle H (2002)
    Expression of telomerase genes in thyroid carcinoma.
    Int J Oncol, 21:265-272
  15. Aust G, Steinert M, Schütz A, Boltze C, Wahlbuhl M, Hamman J, Wobus M (2002)
    CD97, but not its closely related EGF-TM7 family member EMR2 is expressed on gastric, pancreatic and esophageal carcinomas.
    Am J Clin Pathol, 118:699-707
  16. Schneider-Stock R, Boltze C, Jäger V, Stumm M, Seiler C, Rys J, Schütze K, Roessner A (2002)
    Significance of loss of heterozygosity of the RB1 gene during tumour progression in well-differentiated liposarcomas.
    J Pathol, 197:654-660
  17. Hribaschek A, Pross M, Kuhn R, Krüger S, Ridwelski K, Halangk W, Boltze C, Lippert H (2002)
    Prevention and treatment of peritoneal carcinomatosis in experimental investigations with CPT-11 and oxaliplatin.
    Anti-Cancer Drugs, 13:605-614
  18. Mawrin C, Kirches E, Dietzmann K, Roessner A, Boltze C (2002)
    Expression pattern of apoptotic markers in vestibular schwannomas.
    Pathol Res Pract, 198:813-820
  19. Hribaschek A, Ridwelski K, Pross M, Meyer F, Kuhn R, Halangk W, Boltze C, Lippert H (2003)
    Intraperitoneal treatment using Taxol is effective for experimental peritoneal carcinomatosis in a rat model.
    Oncol Rep 10:1793-1798
  20. Schneider-Stock R, Gerresheim F, Kolin-Gerresheim I, Meyer F, Jäger V, Epplen JT, Roessner A, Boltze C (2003)
    Different mRNA expression profile during tumor progression in a well-differentiated liposarcoma – a microdissection approach.
    Pathol Res Pract, 199:445-450
  21. Schneider-Stock R, Giers A, Motsch C, Boltze C, Evert M, Freigang B, Roessner A (2003)
    Hereditary p16-Leiden mutation in a patient with multiple head and neck cancer.
    Am J Hum Genet, 72:216-218
  22. Boltze C, Hribaschek A, Lippert H, Roessner A (2003)
    Intermuscular chondrolipoma of the thigh: the diagnostic way of a rare entity.
    Pathol Res Pract, 199:503-507
  23. Mawrin C, Diete S, Treuheit T, Kropf S, Vorwerk CK, Boltze C, Kirches E, Firsching R, Dietzmann K (2003)
    Prognostic relevance of MAPK expression in glioblastoma multiforme.
    Int J Oncol, 23:641-648
  24. Röpke M, Boltze C, Neumann HW, Roessner A, Schneider-Stock R (2003)
    Genetic and epigenetic alterations in tumor progression of a dedifferentiated chondrosarcoma.
    Pathol Res Pract, 199:437-444
  25. Schneider-Stock R, Boltze C, Jäger V, Epplen J, Landt O, Peters B, Rys J, Roessner A (2003)
    Elevated telomerase activity, c-Myc, and hTERT mRNA expression – markers for tumor progression in malignant lipomatous tumors.
    J Pathol, 199:517-525
  26. Boltze C, Zack S, Quednow C, Bettke S, Roessner A, Schneider-Stock R (2003)
    Hypermethylation of the CDKN2 / p16INK4A promotor in thyroid carcinogenesis.
    Pathol Res Pract, 199:399-404
  27. Boltze C, Schneider-Stock R, Meyer F, Peters B, Quednow C, Hoang-Vu C, Roessner A (2003)
    Maspin in thyroid cancer: its relationship with p53 and clinical outcome.
    Oncol Rep, 10:1783-1788
  28. Mawrin C, Grimm C, von Falkenhausen U, Kirches E, Scherlach C, Kanakis D, Vorwerk C, Boltze C, Firsching R, Dietzmann K (2003)
    Pineal epidermoid coinciding with pineocytoma.
    Acta Neurochir, 145:783-787
  29. Boltze C, Schneider-Stock R, Quednow C, Hinze R, Mawrin C, Hribaschek A, Roessner A, Hoang-Vu C (2003)
    Silencing of the Maspin gene by promoter hypermethylation in thyroid cancer.
    Int J Mol Med, 11:479-484
  30. Schneider-Stock R, Boltze C, Lasota J, Miettinen M, Peters B, Pross M, Roessner A, Günther T (2003)
    High prognostic value of p16INK4 alterations in gastrointestinal stromal tumors.
    J Clin Oncol, 21:1688-1697
  31. Schneider-Stock R, Boltze C, Peters B, Höpfner T, Meyer F, Lippert H, Roessner A (2003)
    Differences in loss of p16INK4A protein expression by promoter methylation between left- and right-sided primary colorectal carcinomas.
    Int J Oncol, 23:1009-1013
  32. Naka T, Boltze C, Samii A, Herold C, Ostertag H, Iwamoto Y, Oda Y, Tsuneyoshi M, Kuester D, Roessner A (2003)
    Skull base and non-scull-base chordomas. Clinicopathologic and immunohistochemical study with special reference to nuclear pleomorphism and proliferative ability.
    Cancer, 98:1934-1941
  33. Boltze C, Schneider-Stock R, Roessner A, Quednow C, Hoang-Vu C (2003)
    Function of HSP90 and p23 in the telomerase complex of thyroid tumors.
    Pathol Res Pract, 199:573-579
  34. Semczuk A, Boltze C, Marzec B, Szczygielska A, Roessner A, Schneider-Stock R (2003)
    p16 INK4A alterations are accompanied by aberrant protein immunostaining in endometrial carcinomas.
    J Cancer Res Clin Oncol, 129:589-596
  35. Lasota J, Dansonka-Mieszkowska A, Stachura T, Schneider-Stock R, Kallajoki M, Steigen SE, Sarlomo-Rikala M, Boltze C, Kordek R, Roessner A, Stachura J, Miettinen M (2003)
    Gastrointestinal stromal tumors with internal tandem duplications in 3' end of KIT juxtamembrane domain occur predominantly in stomach and generally seem to have a favorable course.
    Mod Pathol, 16:1257-1264
  36. Boltze C, Mundschenk J, Unger N, Schneider-Stock R, Peters B, Mawrin C, Hoang-Vu C, Roessner A, Lehnert H (2003)
    Expression profile of the telomeric complex discriminates between benign and malignant pheochromocytoma.
    J Clin Endocrinol Metab, 88:4280-4286
  37. Lasota J, Kopczynski J, Sarlomo-Rikala M, Schneider-Stock R, Stachura T, Kordek R, Michal M, Boltze C, Roessner A, Stachura J, Miettinen M (2003)
    KIT 1530ins6 mutation defines a subset of predominantly malignant gastrointestinal stromal tumors of intestinal origin.
    Hum Pathol, 34:1306-1312
  38. Boltze C, Schneider-Stock R, Quednow C, Gerlach R, Mawrin C, Hinze R, Roessner A, Hoang-Vu C (2003)
    Proteome analysis identified Maspin as a special feature of papillary thyroid carcinoma.
    Int J Oncol, 23:1323-1328
  39. Koon N, Schneider-Stock R, Sarlomo-Rikala M, Lasota J, Smolkin M, Petroni G, Zaika A, Boltze C, Meyer F, Andersson L, Knuutila S, Miettinen M, El-Rifai W (2004)
    Molecular targets for tumor progression in gastrointestinal stromal tumors (GISTs).
    Gut, 53:235-240
  40. Dworakowska D, Jassem E, Jassem J, Wiedorn KH, Boltze C, Karmolinski A, Dworakowski R, Skokowski J, Jaskiewicz K, Bosse A, Czestochowska E (2004)
    Prognostic Relevance of Altered pRb and p53 Protein Expression in Surgically Treated Non-Small Cell Lung Cancer Patients.
    Oncology, 67:60-66
  41. Schneider-Stock R, Boltze C, Peters B, Szibor R, Landt O, Meyer F, Roessner A (2004)
    Selective loss of codon 72 proline p53 and frequent mutational inactivation of the retained arginine allele in colorectal cancer.
    Neoplasia, 6:529-535
  42. Motsch C, Giers A, Boltze C, Evert M, Freigang B, Roessner A, Schneider-Stock R (2004)
    Biallelic inactivation of the p16 gene in three metachronous carcinoma of the oropharynx.
    Laryngo Rhino Otol, 83:55-60
  43. Boltze C (2004)
    Animal models of thyroid carcinogenesis.
    Cancer Treat Res, 122:273-293
  44. Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al-Hmaira J, Hartig R, Roessner A, Schneider-Stock R (2004)
    Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism.
    Int J Oncol, 25:857-866
  45. Naka T, Boltze C, Kuester D, Schulz TO, Samii A, Herold C, Ostertag H, Roessner A (2004)
    Expression of Matrix Metalloproteinase (MMP)-1, MMP-2, MMP-9, cathepsin B, and urokinase plasminogen activator in non-skull base chordoma.
    Am J Clin Pathol, 122:926-930
  46. Schneider-Stock R, Mawrin C, Motsch C, Boltze C, Peters B, Hartig R, Buhtz P, Giers A, Rohrbeck A, Freigang B, Roessner A (2004)
    Retention of the arginine allele in codon 72 of the p53 gene correlates with poor apoptosis in head and neck cancer.
    Am J Pathol, 164:1233-1241
  47. Schneider-Stock R, Boltze C, Lasota J, Peters B, Corless CL, Ruemmele P, Terracciano L, Pross M, Insabato L, Di Vizio D, Iesalnieks I, Dirnhofer S, Hartmann A, Heinrich M, Miettinen M, Roessner A, Tornillo L (2005)
    Loss of p16 protein defines high-risk patients with Gastrointestinal Stromal Tumors - A tissue microarray study.
    Clin Cancer Res, 11: 638-645
  48. Naka T, Boltze C, Kuester D, Samii A, Herold C, Ostertag H, Iwamoto Y, Oda Y, Tsuneyoshi M, Roessner A (2005)
    Histogenesis of intralesional fibrous septum in chordoma.
    Pathol Res Pract, 201:443-447
  49. Mawrin A, Kirches E, Schneider-Stock R, Boltze C, Vorwerk CK, Deimling A, Stoltenburg-Didinge G, Bornemann A, Romeike B, Sellhaus B, Dietzmann K (2005)
    Alterations of cell cycle regulators in gliomatosis cerebri.
    J Neurooncol, 72:115-122
  50. Dworakowska D, Jassem E, Jassem J, Boltze C, Wiedorn KH, Dworakowski R, Skokowski J, Jaskiewicz K, Czestochowska E (2005)
    Absence of prognostic significance of p21(WAF1/CIP1) protein expression in non-small cell lung cancer.
    Acta Oncol, 44: 75-79
  51. Schneider-Stock R, Diab-Asseff M, Rohrbeck A, Foltzer-Jourdainne C, Boltze C, Hartig R, Schönfeld P, Roessner A, Gali-Muhtasib H (2005)
    5-AZA-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms.
    J Pharmacol Exp Ther, 312:525-536
  52. Dworakowska D, Jassem E, Jassem J, Boltze C, Wiedorn KH, Dworakowski R, Skokowski J, Jaskiewicz K, Czestochowska E (2005)
    Prognostic value of cyclin D1 overexpression in correlation with pRb and p53 status in non-small cell lung cancer (NSCLC).
    J Cancer Res Clin Oncol, 131:479-485
  53. Naka T, Boltze C, Kuester D, Schulz TO, Schneider-Stock R, Kellner A, Samii A, Herold C, Ostertag H, Roessner A (2005)
    Alterations of G1-S checkpoint in chordoma: Prognostic impact of p53 overexpression.
    Cancer, 104:1255-1263
  54. Boltze C (2005)
    Loss of maspin is a helpful prognosticator in colorectal cancer: A tissue microarray analysis.
    Pathol Res Pract, 200:783-790
  55. Naka T, Boltze C, Kuester D, Samii A, Herold C, Ostertag H, Iwamoto Y, Oda Y, Tsuneyoshi M, Roessner A (2005)
    Intralesional fibrous septum in chordoma: A clinicopathologic and immunohisto-chemical study of 122 lesions.
    Am J Clin Pathol, 124:288-294
  56. Hribaschek A, Kuhn R, Pross M, Meyer F, Fahlke J, Ridwelski K, Boltze C, Lippert H (2006)
    Comparison of intraperitoneal versus intravenous CPT-11 given intra- and postoperatively for peritoneal carcinomatosis in a rat model.
    Surg Today, 36:57-62
  57. Röpke M, Boltze C, Meyer B, Neumann HW, Roessner A, Schneider-Stock R (2006)
    Rb-loss is associated with high malignancy in chondrosarcoma.
    Oncol Rep, 15:89-95
  58. Schneider-Stock R, Kuester D, Ullrich O, Mittag F, Habold C, Boltze C, Peters B, Krueger S, Hintze C, Meyer F, Hartig R, Roessner A (2006)
    Close localization of DAP-kinase positive tumor-associated macrophages and apoptotic colorectal cancer cells.
    J Pathol, 209:95-105
  59. Aust G, Wandel E, Boltze C, Sittig, D, Steinert M, Schütz A, Horn LC, Wobus M (2006)
    Diversity of CD97 in smooth muscle cells (SMCs).
    Cell Tissue Res, 324:139-147
  60. Just T, Stave J, Boltze C, Wree A, Kramp B, Guthoff RF, Pau HW (2006)
    Laser scanning microscopy of the human larynx mucosa: a preliminary, ex vivo study.
    Laryngoscope, 116:1136-1141
  61. Port M, Boltze C, Wang Y, Roper B, Meineke V, Abend M (2007)
    A radiation-induced gene signature distinguishes post-Chernobyl from sporadic papillary thyroid cancers.
    Rad Res, 168:639-649
  62. Zehlike T, Punke C, Haase K, Boltze C, Pau HW (2008)
    Myxoma of the middle ear-a rare cause of facial palsy.
    HNO, 56:165-168
  63. Zehlike T, Punke C, Boltze C, Pau HW (2008)
    Transient Facial Palsy in Two Cases of Benign, Very Rare Middle Ear Tumors (Carcinoid Tumor and Myxoma).
    Neurologist, 14:52-55
  64. Naka T, Kuester D, Boltze C, Schulz TO, Samii A, Herold C, Ostertag H, Roessner A (2008)
    Expression of matrix metalloproteinases-1, -2, and -9; tissue inhibitors of matrix  metalloproteinases-1 and -2; cathepsin B; urokinase plasminogen activator; and plasminogen activator inhibitor, type I in skull base chordoma.
    Hum Pathol, 39:217-223
  65. Naka T, Kuester D, Boltze C, Scheil-Bertram S, Samii A, Herold C, Ostertag H, Krueger S, Roessner A (2008)
    Expression of hepatocyte growth factor and c-MET in skull base chordoma.
    Cancer, 112:104-110

Übersichtsartikel

  1. Roessner A, Schneider-Stock R, Boltze C (2001)
    Pathology of soft tissue tumors.
    Viszeralchir, 36: 203-208
  2. Boltze C, Heutling D, Lehnert H (2002)
    Molecular pathogenesis of endocrine tumors.
    Internist, 43:157-173
  3. Schneider-Stock R, Giers A, Boltze C, Evert M, Freigang B, Roessner A, Motsch C (2003)
    Molekulargenetik als wichtige Säule der Tumordiagnostik: Identifizierung erblicher Karzinompatienten.
    Tumorz akt, 1:4-8
  4. Boltze C, Hoang-Vu C, Schneider-Stock R, Lehnert H, Roessner A (2004)
    Role of the class II tumor suppressor gene maspin in thyroid carcinogenesis.
    Verh Dtsch Ges Pathol, 88:237-245

Weitere Publikationen

Buchbeiträge

  1. Hoang-Vu C, Boltze C, Sekulla C, Dralle H, Gerlach R, Dunst J, Holzhausen HJ, Brabant G.
    Functional and histomorphological changes of thyrocytes under different iodine intake and external ionizing radiation in rats.
    In: Thomas G, Karaoglou A, Williams ED (Eds.): Radiation and thyroid cancer. World Scientific, Singapur, New Jersey, London, Hongkong, 1999, pp 209-212
  2. Schneider-Stock R, Boltze C, Roessner A.
    Telomerase activity in mesenchymal tumors.
    In: Krupp G, Pawaresch R (Eds.): Telomeres and Telomerases: Cancer and Biology. LandesBioscience / Eurekah.com, Georgetown,TX, 2002, pp 41-46
  3. Boltze C.
    Animal models of thyroid carcinogenesis.
    In: Farid NR (Ed.): Molecular basis of thyroid cancer. Kluwer Academic Publishers, Norwell, MA, 2004, pp 272-293

Posterpräsentationen mit publizierten Abstracts

  1. Boltze C, Gerlach R, Dunst J, Dralle H, Brabant G, Hoang.Vu C.
    Histomorphologische und funktionelle Veränderungen der Schilddrüsenzellen von Ratten unter Jodvarianz und Radiatio
    34. Wissenschaftliche Tagung der Gesellschaft für Versuchstierkunde, Jena, 1997
  2. Boltze C, Gerlach R, Dunst J, Dralle H, Brabant G, Hoang.Vu C.
    Effects of nutrition iodine and radiation on hormonal and histomorphological changes of thyroid gland in rats.
    42. Symposion der Deutschen Gesellschaft für Endokrinologie, Freiburg, 1998
  3. Boltze C, Gerlach R, Holzhausen HJ, Dralle H, Brabant G, Hoang-Vu C.
    Protective role of iodine supplementation after external ionizing radiation in rats.
    43. Symposion der Deutschen Gesellschaft für Endokrinologie, Kiel, 1999
  4. Hoang-Vu C, Hammje K, Bull K, Scholle B, Boltze C, Holzhausen HJ, Hädicke J, Poremba C, Dockhorn-Dworniczak B, Schneyer U, Rath FW, Dralle H. Telomerase activity and expression of telomerase components in benign goitres and thyroid carcinomas.
    26th Annual Meeting of the European Thyroid Association, Mailand, 1999
  5. Boltze C, Scholle B, Spens A, Schmutzler C, Köhrle J, Dralle H, Hoang-Vu C.
    Involvement of metalloproteinases and their inhibitors in the process of tumour invasion and metastasis of thyroid carcinomas.
    3. Chirurgische Forschungstage, Marburg, 1999
  6. Hinze R, Boltze C, Meye A, Rath FW.
    Expression of the von Hippel-Lindau tumor suppressor gene in nonneoplastic and neoplastic lesions of the thyroid.
    84. Jahrestagung der Deutschen Gesellschaft für Pathologie, Kiel, 2000
  7. Boltze C, Köhrle J, Dralle H, Rath FW, Hoang-Vu C.
    Regulation of metalloproteinases and their inhibitors in the human follicular thyroid carcinoma cell line FTC-133.
    84. Jahrestagung der Deutschen Gesellschaft für Pathologie, Kiel, 2000
  8. Boltze C, Dralle H, Brabant G, Roessner A, Hoang-Vu C.
    Triiodothyronin (T3) – an essential growth factor in rats.
    12th International Thyroid Congress, Kyoto, 2000       
    Posterpreis
  9. Wobus M, Steinert M, Schütz A, Boltze C, Wahlbuhl M, Hamann J, Aust G.
    Expression of CD97 in colorectal tumor cells and its involvement in migration and invasion.
    International Meeting “Invasion and Metastasis”, Amsterdam, 2001
  10. Schneider-Stock R, Hauptmann K, Boltze C, Schulz T, Roessner A.
    Potential molecular markers of giant cell tumors of bone versus aneurysmatic bone cysts.
    85. Jahrestagung der Deutschen Gesellschaft für Pathologie, Münster, 2001
  11. Schneider-Stock R, Boltze C, Peters B, Landt O, Rys J, Jaeger V, Roessner A.
    Elevated c-Myc mRNA expression as an indicator for tumor progression in malignant lipomatous tumors.
    92nd AACR Annual Meeting, New Orleans, 2001
  12. Wolf H, Boltze C, Bentlage I, Kasper HU, Wallenhorst A, Roessner A.
    Inducible nitric oxide synthase as a modulator of microvessel density in colorectal adenomas, carcinomas and liver metastases.
    85. Jahrestagung der Deutschen Gesellschaft für Pathologie, Münster, 2001
  13. Wallenhorst A, Boltze C, Kasper HU, Wolf H, Bentlage I, Roessner A.
    Expression of thrombospondin-1 (TSP-1) as a modulator of angiogenesis in colorectal adenomas, carcinomas and its liver metastases: correlation with microvessel density (MVD).
    85. Jahrestagung der Deutschen Gesellschaft für Pathologie, Münster, 2001
  14. Boltze C, Schneider-Stock R, Dralle H, Roessner A, Hoang-Vu C.
    Expression and regulation of telomerase genes in thyroid carcinoma.
    92nd AACR Annual Meeting, New Orleans, 2001
  15. Boltze C, Schneider-Stock R, Krueger S, Roessner A.
    In-vitro model for characterization of heat shock proteins and proteases in cancer cell lines of different malignant potential.
    85. Jahrestagung der Deutschen Gesellschaft für Pathologie, Münster, 2001
  16. Dworakowska D, Jassem E, Wiedorn K, Dziadziuszko R, Boltze C, Kobierska R, Skokowski J, Bosse A, Jassem J. Zaburzenia
    ekspresji genów MDM2 i P53 w niedrobnokomórkowym raku płuca
    Kongres Onkologii Polskiej, Katowice, 2002
  17. Schneider-Stock R, Günther T, Lasota J, Miettinen M, Boltze C, Roessner A.
    p16INK4 pathway dysregulation in gastrointestinal stromal tumors.
    93rd AACR Annual Meeting, San Francisco, 2002
  18. Aust G, Steinert M, Boltze C, Schütz A, Wobus M.
    CD97 is a migration and invasion associated molecule in colorectal carcinomas.
    6. Chirurgische Forschungstage, Köln, 2002
  19. Hribaschek A, Ridwelski K, Boltze C, Pross M, Meyer F, Halangk W, Lippert H.
    uperior efficacy of intraperitoneal (ip) compared with intravenous (iv) CPT-11 in a rat model of peritoneal carcinomatosis
    8th Annual Meeting of the American Society of Clinical Oncology (ASCO), Orlando, 2002
  20. Eyer J, Boltze C, Spens A, Leder S, Dansranjavin T, Sekulla C, Graf von Matuschka C, Dralle H, Hoang-Vu C.
    Expression of CD97-isoforms in pancreatic tissues.
    45. Symposion der Deutschen Gesellschaft für Endokrinologie, Magdeburg, 2002
  21. Leder S, Boltze C, Gimm O, Bernstein A, Dammann R, Sutter T, Dralle H, Hoang-Vu C.
    Analyse der Expression von CD97 und seinen Isoformen in normalem Magengewebe, Magenulkus und Magenkarzinomen.
    25. Deutscher Krebskongress, Berlin, 2002
  22. Schneider-Stock R, Boltze C, Peters B, Szibor R, Landt O, Roessner A.
    p53-LOH in codon 72 of exon 4 in colorectal cancer and liver metastases is associated with preferential loss of the proline allele.
    93rd AACR Annual Meeting, San Francisco, 2002
  23. Boltze C, Schneider-Stock R, Aust G, Dralle H, Roessner A, Hoang-Vu C.
    Fas, Fas-L and CD97 as distinction markers between chronic pancreatitis and pancreatic ductal adenocarcinoma in perioperative evaluation of cryocut sections.
    46. Symposion der Deutschen Gesellschaft für Endokrinologie, Göttingen, 2002
  24. Boltze C, Brabant G, Dralle H, Roessner A, Hoang-Vu C.
    Growth process in rats is strictly associated with T3.
    46. Symposion der Deutschen Gesellschaft für Endokrinologie, Göttingen, 2002
  25. Boltze C, Schneider-Stock R, Roessner A, Hoang-Vu C.
    Expression, regulation and modification of matrixmetalloproteinases and their naturally occurring inhibitors in thyroid carcinoma in-vitro and in-vivo.
    93rd AACR Annual Meeting, San Francisco, 2002
  26. Boltze C, Schneider-Stock R, Aust G, Dralle H, Roessner A, Hoang-Vu C.
    CD97, CD95 and FAS-L clearly discriminate between chronic pancreatitis and pancreatic ductal adenocarcinoma in perioperative evaluation of cryocut sections.
    86. Jahrestagung der Deutschen Gesellschaft für Pathologie, Wien, 2002
  27. Jassem J, Dworakowska D, Jassem E, Dworakowski R, Wiedorn K, Boltze C, Skokowski J, Jaskiewicz K, Czestochowska E, Bosse A.
    The prognostic value of altered pRb and p53 protein expression in surgically treated non-small cell lung cancer patients
    10th World Conference on Lung Cancer, Vancouver, 2003
  28. Dworakowska D, Jassem E, Dworakowski R, Wiedorn K, Boltze C, Skokowski J, Jaskiewicz K, Czestochowska E, Bosse A, Jassem J.
    The prognostic value of altered pRb and p53 protein expression in non-small cell lung cancer.
    13th ERS Annual Congress, Wien, 2003
  29. Meyer F, Boltze C, Mittag F, Vieth M, Höpfner T, Peters B, Lippert H, Roessner A, Schneider-Stock R.
    DAPK promotor hypermethylation correlates with reduced Fas/FasL-induced apoptosis in colorectal cancer.
    58. Jahrestagung der Deutschen Gesellschaft für Verdauungs- und Stoffwechsel-krankheiten (DGVS), Nürnberg, 2003
  30. Mittag F, Boltze C, Meyer F, Roessner A, Schneider-Stock R.
    Aberrant promotor methylation in proximal and distal colorectal carcinomas
    94th AACR Annual Meeting, Washington, 2003
  31. Meyer F, Boltze C, Vieth M, Mittag F, Höpfner T, Peters B, Lippert H, Roessner A, Schneider-Stock R.
    p16INK4 promotermethylation and loss of p16INK4 protein expression is an early event in colorectal carcinogenesis.
    12. Kongress der Mitteldeutschen Gesellschaft für Gastroenterologie, Magdeburg, 2003
    Posterpreis
  32. Peters B, Boltze C, Meyer F, Roessner A, Schneider-Stock R.
    Konfigurationsfrequenz-analyse zum Erkennen von typischen Promotormethylierungsmustern von P16, DAPK, hHMLH1 und MGMT.
    48. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS) e.V, Münster, 2003
  33. Gali-Muhtasib HU, Boltze C, Diab-Assaf M, Al-Hmaira J, Roessner A, Schneider-Stock R.
    Thymoquinone extracted from black seed is a potent growth inhibitor and inducer of apoptosis in human colon cancer HCT-116 cells.
    94th AACR Annual Meeting, Washington, 2003
  34. Boltze C, Mundschenk J, Unger N, Schneider-Stock R, Hoang-Vu C, Roessner A, Lehnert H.
    Expression profile of the telomeric complex as an indicator of malignancy in pheochromocytomas.
    6th European Congress of Endocrinology, Lyon, 2003
  35. Boltze C, Schneider-Stock R, Hoang-Vu C, Köhrle J, Roessner A.
    Expression, regulation and modification of matrixmetalloproteinases and their naturally occurring inhibitors in thyroid carcinoma in-vitro and in-vivo.
    87. Jahrestagung der Deutschen Gesellschaft für Pathologie, Bamberg, 2003
  36. Boltze C, Funke T, Roessner A, Schneider-Stock R.
    Increased MMP-13 protein is associated with high TIMP-1 and-2 levels and better prognosis in colorectal carcinomas.
    87. Jahrestagung der Deutschen Gesellschaft für Pathologie, Bamberg, 2003
  37. Boltze C, Roessner A, Hoang-Vu C, Schneider-Stock R.
    Fas/Fas-L mediated apoptosis differs between histological subtypes of thyroid neoplasms.
    87. Jahrestagung der Deutschen Gesellschaft für Pathologie, Bamberg, 2003
  38. Hribaschek A, Meyer F, Ridwelski C, Pross M, Halangk W, Boltze C, Lippert H.
    Significant benefit of the novel cytostatic drugs irinotecan and oxaliplatin in limiting peritoneal tumor growth depending on the application route in rats
    95th AACR Annual Meeting, Orlando, 2004
  39. Dworakowska D, Jassem E, Jassem J, Boltze C, Wiedorn KH, Karmolinski A, Dworakowski R, Łapiński M, Tomaszewski D, Skokowski J, Jaskiewicz K, Czestochowska E.
    p21WAF1/CIP1 and p53 protein expression in non-small-cell lung cancer (NSCLC)
    9th Central European Lung Cancer Conference, Gdańsk, 2004
  40. Dworakowska D, Jassem E, Jassem J, Boltze C, Wiedorn KH, Karmolinski A, Dworakowski R, Łapiński M, Tomaszewski D, Skokowski J, Jaskiewicz K, Bosse A, Czestochowska E.
    Prognostic value of altered cyclin D1 expression in non-small cell lung cancer
    14th ERS Annual Congress, Glasgow, 2004
  41. Schneider-Stock R, Boltze C, Mittag F, Vieth M, Peters B, Hartig R, Meyer F, Rossner A.
    DAPK promotor hypermethylation correlates with reduced apoptosis in colorectal cancer.
    88. Jahrestagung der Deutschen Gesellschaft für Pathologie, Rostock, 2004
  42. Boltze C, Hoang-Vu C, Schneider-Stock R, Lehnert H, Roessner A.
    Role of the class II tumor suppressor gene maspin in thyroids.
    88. Jahrestagung der Deutschen Gesellschaft für Pathologie, Rostock, 2004
    Posterpreis
  43. Aust G, Sittig D, Boltze C, Horn LC, Schütz A, Wobus M.
    CD97 in smooth muscle cells (SMCs) is biochemically and functionally distinct from the molecule in leukocytes and carcinoma cell lines.
    100. Jahrestagung der Deutschen Anatomischen Gesellschaft, Leipzig, 2005
  44. Schneider-Stock R, Boltze C, Küster D, Ullrich O, Mittag F, Peter B, Krüger S, Meyer F, Hintze C, Hartig R, Roessner A.
    DAP-kinase positive tumor-associated macrophages induce apoptotic cell death in colorectal cancer cells
    96th AACR Annual Meeting, Anaheim, 2005
  45. Just T, Stave J, Boltze C, Wree A, Kramp B, Guthoff R, Pau HW.
    Konfokale Laser Scanning Mikroskopie des Kehlkopfkarzinoms und seiner Vorstufen – eine ex vivo Studie
    77. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Mannheim, 2006

Vorträge mit publizierten Abstracts

  1. Boltze C, Gerlach R, Dunst J, Dralle H, Brabant G, Hoang-Vu C.
    Histomorphologische Veränderungen von Rattenschilddrüsenzellen unter Jodmangel.
    12. Internationale Arbeitstagung Experimentelle Schilddrüsenforschung, Berlin, 1996
  2. Boltze C, Gerlach R, Dunst J, Dralle H, Brabant G, Hoang-Vu C.
    Hormonale und histomorphologische Effekte von Jodvarianz und Radiatio auf Thyreozyten von Ratten.
    13. Internationale Arbeitstagung Experimentelle Schilddrüsenforschung, München, 1997
  3. Schmutzler C, Hoang-Vu C, Winzer R, Boltze C, Köhrle J.
    Retinoid effects in thyroid carcinoma cell lines indicate feasibility of a redifferentiation therapy of thyroid cancer.
    International Symposium Thyroid Cancer, Linz, 1998
  4. Hoang-Vu C, Boltze C, Sekulla C, Dralle H, Gerlach R, Dunst J, Holzhausen HJ, Brabant G.
    Functional and histomorphological changes of thyrocytes under different iodine intake and external ionizing radiation in rats.
    International Seminar Radiation and Thyroid Cancer, Cambridge, 1998
  5. Boltze C, Gerlach R, Holzhausen HJ, Dralle H, Brabant G, Hoang-Vu C.
    Gewichtsentwicklung bei Ratten unter Jodvarianz und Radiatio.
    14. Internationale Arbeitstagung Experimentelle Schilddrüsenforschung, Lübeck, 1998
  6. Hoang-Vu C, Boltze C, Spens A, Düren C, Besler K, Nguyen-Thanh P, Sutter T, Dralle H.
    Expression of CD97, Fas and Fas-Ligand in pancreatic carcinomas.
    3. Chirurgische Forschungstage, Marburg, 1999
  7. Mayr B, Boltze C, Hoang-Vu C, Dralle H, Helmbrecht K, von Wasielewski R, von zur Mühlen A, Brabant G.
    Early stimulation of NIS mRNA and protein expression by iodine deficiency in rat thyroid.
    26th Annual Meeting of the European Thyroid Association, Mailand, 1999
  8. Boltze C, Rath FW, Dralle H, Hoang-Vu C.
    Expression of telomerase related genes in thyroid tissues.
    15. Internationale Arbeitstagung Experimentelle Schilddrüsenforschung, Berlin, 1999
  9. Hoang-Vu C, Eyer J, Boltze C, Spens A, Düren C, Kubis D, Graf von Matuschka C, Dralle H.
    Expression von CD97 - Isoformen in Pankreaskarzinomen.
    4. Chirurgische Forschungstage, Lübeck, 2000
  10. Eyer J, Boltze C, Graf von Matuschka C, Hoang-Vu C, Dralle H.
    Expression von CD97 und seinen Isoformen in Pankreaskarzinomen.
    10. Kongress der Chirurgenvereinigung Sachsen-Anhalt, Halle 2000
  11. Hoang-Vu C, Boltze C, Düren C, Dralle H.
    Clinical relevance of the expression of death-domain-receptors in thyroid tissues.
    Millennium Meeting of American and British Associations of Endocrine Surgeons, London, 2000
  12. Boltze C, Schneider-Stock R, Aust G, Roessner A.
    Molekulare Dedifferenzierungsmarker in kolorektalen Karzinomen.
    31. Herbsttagung der Deutschen Gesellschaft für Pathologie, Bonn, 2000
  13. Schulz T, Schneider-Stock R, Boltze C, Roessner A.
    Molecular insights into dedifferen-tiation process of well-differentiated liposarcoma – a case report.
    85. Jahrestagung der Deutschen Gesellschaft für Pathologie, Münster, 2001
  14. Aust G, Steinert M, Boltze C, Schuetz A, Wahlbuhl A, Hamann J, Wobus M.
    CD97 expression in colorectal carcinomas and tumour cell lines.
    11th European Cancer Conference, Lissabon, 2001
  15. Boltze C, Schneider-Stock R, Hoang-Vu C, Roessner A.
    Coexpression of telomeric catalytic subunit (hTERT) and c-Myc correlates with dedifferentiation in thyroid carcinomas.
    45. Symposion der Deutschen Gesellschaft für Endokrinologie, Magdeburg, 2001
  16. Boltze C, Schneider-Stock R, Hoang-Vu C, Roessner A.
    Telomeric catalytic subunit and c-Myc correlates with dedifferentiation in thyroid carcinomas.
    85. Jahrestagung der Deutschen Gesellschaft für Pathologie, Münster, 2001
  17. Steinert M, Wobus M, Boltze C, Schütz A, Eichfeld U, Aust G.
    CD97- sowie EMR2- Expression in Tumorzell-Linien und kolorektalen Karzinomen
    2. Mitteldeutscher Chirurgenkongress, Leipzig, 2002
  18. Giers A, Boltze C, Motsch C, Freigang B, Roessner A, Schneider-Stock R.
    p16- und p53-Alterationen bei fortgeschrittenen Plattenepithelkarzinomen aus dem Kopf-Halsbereich.
    Deutsch-Österreichischer HNO-Kongress, Baden-Baden, 2002
  19. Boltze C, Mundschenk J, Unger N, Schneider-Stock R, Roessner A, Lehnert H.
    Expression profile of the telomeric complex discriminates between benign and malignant pheochromocytoma.
    46. Symposion der Deutschen Gesellschaft für Endokrinologie, Göttingen, 2002
  20. Boltze C.
    Radiation-induced thyroid carcinogenesis as function of time and dietary iodine supply - An in-vivo model of tumorigenesis in the rat.
    46. Symposion der Deutschen Gesellschaft für Endokrinologie, Göttingen, 2002
    European Merck Thyroid Von-Basedow-Research-Prize
  21. Schneider-Stock R, Boltze C, Motsch C, Mawrin C, Giers A, Freigang B, Roessner A.
    Retention of the arginine allele in codon 72 of the p53 gene correlates with poor apoptosis in head and neck cancer.
    87. Jahrestagung der Deutschen Gesellschaft für Pathologie, Bamberg, 2003
  22. Zack S, Bettge S, Boltze C.
    Promoter hypermethylation of p16INK4A and p21 in thyroid carcinogenesis.
    19. Internationale Arbeitstagung Experimentelle Schilddrüsenforschung, Halle, 2003
    Vortragspreis
  23. Schneider-Stock R, Boltze C, Mittag F, Meyer F, Roessner A.
    Aberrant promotor methylation in proximal and distal colorectal cancer.
    87. Jahrestagung der Deutschen Gesellschaft für Pathologie, Bamberg, 2003
  24. Schneider-Stock R, Boltze C, Lasota J, Miettinen M, Dirnhofer S, Terracciano L, Tornillo L, Peters B, Pross M, Corless C , Günther T, Roessner A.
    Prognostic significance of p16INK4 alterations in gastrointestinal stromal tumors.
    87. Jahrestagung der Deutschen Gesellschaft für Pathologie, Bamberg, 2003
  25. Boltze C, Roessner A, Lehnert H, Schneider-Stock R.
    Expression profile of the telomeric complex discriminates between benign and malignant pheochromocytoma.
    87. Jahrestagung der Deutschen Gesellschaft für Pathologie, Bamberg, 2003
  26. Boltze C, Zack S, Quednow C, Roessner A, Schneider-Stock R.
    Role of promotor hypermethylation of the p16INK4 and DAPK genes in thyroid carcinogenesis.
    87. Jahrestagung der Deutschen Gesellschaft für Pathologie, Bamberg, 2003
  27. Boltze C, Giers A, Motsch C, Freigang B, Roessner A, Schneider-Stock R.
    Methylation of the p16INK4 promotor as the second genetic hit in patient with multiple head and neck cancer bearing a hereditary p16-Leiden mutation.
    87. Jahrestagung der Deutschen Gesellschaft für Pathologie, Bamberg, 2003
    Vortragspreis
  28. Boltze C, Zack S, Bettge S, Roessner A, Schneider-Stock R.
    Promoter hypermethylation of CDKN2/ p16INK4A and WAF1/ p21 in thyroid carcinogenesis.
    8th World Congress on Advances in Oncology and 6th International Symposium on Molecular Medicine, Hersonissos, Kreta, 2003
  29. Dworakowska D, Jassem E, Jassem J, Boltze C, Wiedorn KH, Karmolinski A, Dworakowski R, Łapiński M, Tomaszewski D, Skokowski J, Jaskiewicz K, Bosse A, Czestochowska E.
    Prognostic value of p21 protein expression in non-small cell lung cancer.
    14th ERS Annual Congress, Glasgow, 2004
  30. Schneider-Stock R, Boltze C, Peters B, Giers A, Freigang B, Roessner A, Motsch C.
    Methylation of the MGMT promoter correlates with unfavourable prognosis in patients with advanced head and neck cancer.
    75. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bad Reichenhall, 2004
  31. Dworakowska D, Jassem E, Jassem J, Boltze C, Wiedorn KH, Karmolinski A, Dworakowski R, Łapiński M, Tomaszewski D, Skokowski J, Jaskiewicz K, Czestochowska E.
    Cyclin D1 overexpression in correlation with pRb and p53 status in non-small-cell lung cancer (NSCLC).
    9th Central European Lung Cancer Conference, Gdańsk, 2004
  32. Kuhn R, Schneider-Stock R, Boltze C, Lasota J, Peters B, Corless C, Ruemmele P, Miettinen M, Pross M.
    Ein p16 Proteinverlust definiert Hoch-Risiko Patienten mit gastrointestinalen Stromatumoren.
    122. Kongress der Deutschen Gesellschaft für Chirurgie, München, 2005
  33. Zehlicke T, Punke C, Boltze C, Dommerich S, Pau HW.
    Intrabulläre Applikation von neu entwickelten Knochenersatzmaterialien beim Meerschweinchen.
    77. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Mannheim, 2006
  34. Boltze C, Abend M, Nizze H.
    Proteomics of radiation induced thyroid carcinomas.
    90. Jahrestagung der Deutschen Gesellschaft für Pathologie, Berlin, 2006
  35. Sarajian HR, Boltze C, Gundlach KKH.
    Vergleichende in vivo Untersuchung zum biologischen Verhalten unterschiedlicher bioresorbierbarer Osteosyntheseplatten.
    56. Kongress der Deutschen Gesellschaft für Mund-, Kiefer- und Gesichtschirurgie, Dresden 2006
  36. Zehlicke T, Punke C, Boltze C, Pau HW.
    Tumoren des Mittelohres als seltene Ursache einer Fazialisparese.
    77. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V., Mannheim, 2006


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